The video makes a very good point. Much of the death to the native tribes in the Americas occurred in the 1500s. The wars against the ‘Indians/Native Americans/ etc” were European settlers waging wars against peoples that had been truly devastated two and three centuries before.
It doesn’t excuse what occurred in those after centuries, but the mass death was a truly great tragedy of history. It might have been the biggest dying of humans in history, with estimates of up to 90% of the native tribes being dying from disease and plagues.